BMPR1B polyclonal antibody
产品名称： BMPR1B polyclonal antibody
英文名称： BMPR1B polyclonal antibody
产品编号： PAB3837
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BMPR1B.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BMPR1B.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.
Lehmann K, Seemann P, Stricker S, Sammar M, Meyer B, Suring K, Majewski F, Tinschert S, Grzeschik KH, Muller D, Knaus P, Nurnberg P, Mundlos S.Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12277-82. Epub 2003 Oct 1.
- 2.
- Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
Astrom AK, Jin D, Imamura T, Roijer E, Rosenzweig B, Miyazono K, ten Dijke P, Stenman G.Mamm Genome. 1999 Mar;10(3):299-302.
- 3.
- Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs.
Ide H, Katoh M, Sasaki H, Yoshida T, Aoki K, Nawa Y, Osada Y, Sugimura T, Terada M.Oncogene. 1997 Mar 20;14(11):1377-82.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of BMPR1B polyclonal antibody (Cat # PAB3837) in NCI-H460 cell lysate (Lane A) and mouse heart tissue lysate (Lane B) . BMPR1B (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Entrez GeneID:
- 658
- Protein Accession#:
- NP_001194
- Gene Name:
- BMPR1B
- Gene Alias:
- ALK-6,ALK6,CDw293
- Gene Description:
- bone morphogenetic protein receptor, type IB
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq
- Other Designations:
- OTTHUMP00000161622,activin receptor-like kinase 6,serine/threonine receptor kinase